XCR1 antibody (Chemokine (C Motif) Receptor 1) (AA 305-333)

Details for Product anti-XCR1 Antibody No. ABIN655980, Supplier: Log in to see
Antigen
  • CCXCR1-L
  • XCR1
  • CCXCR1
  • GPR5
  • Ccxcr1
  • Gpr5
  • mXcr1
  • chemokine (C motif) receptor 1
  • XC chemokine receptor 1
  • XCR1
  • xcr1a
  • Xcr1
  • LOC100352332
Epitope
AA 305-333, C-Term
18
17
16
16
16
11
9
5
4
3
3
2
2
1
Reactivity
Human
72
14
12
1
1
1
Host
Rabbit
59
15
12
Clonality (Clone)
Polyclonal ()
Conjugate
This XCR1 antibody is un-conjugated
9
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
Application
Western Blotting (WB)
33
29
27
21
19
6
4
2
2
2
1
1
1
1
Options
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Immunogen This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-333 AA from the C-terminal region of human XCR1.
Clone RB31951
Isotype Ig
Specificity This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-333 amino acids from the C-terminal region of human XCR1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name XCR1 (XCR1 Antibody Abstract)
Background The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms: XCR1,Chemokine XC receptor 1,CCXCR1, GPR5
Molecular Weight 38508 DA
Gene ID 2829
NCBI Accession NP_005274
UniProt P46094
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-XCR1 antibody (Chemokine (C Motif) Receptor 1) (AA 305-333) (ABIN655980) XCR1 Antibody (C-term) (ABIN655980) western blot analysis in MDA-MB435 cell line lysa...
Background publications Yamazaki, Miyamoto, Hoshino, Fukuda, Sasaki, Saito, Ishiguchi, Yano, Sugiyama, Hemmi, Tanaka, Hamada, Hirashima, Amakawa, Fukuhara, Nomura, Ito, Kaisho: "Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 756-61, 2010 (PubMed).

Crozat, Guiton, Contreras, Feuillet, Dutertre, Ventre, Vu Manh, Baranek, Storset, Marvel, Boudinot, Hosmalin, Schwartz-Cornil, Dalod: "The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1283-92, 2010 (PubMed).

Bachem, Güttler, Hartung, Ebstein, Schaefer, Tannert, Salama, Movassaghi, Opitz, Mages, Henn, Kloetzel, Gurka, Kroczek: "Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1273-81, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).