Chemokine (C Motif) Receptor 1 (XCR1) (C-Term), (AA 305-333) antibody

Details for Product No. ABIN655980
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Antigen
Synonyms GPR5, CCXCR1, Ccxcr1, Gpr5, mXcr1, CCXCR1-L, XCR1
Epitope
C-Term, AA 305-333
(4), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(23)
Host
Rabbit
(19), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1)
Application
Western Blotting (WB)
(15), (7), (6), (4), (2), (2), (2)
Pubmed 4 references available
Catalog no. ABIN655980
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-333 AA from the C-terminal region of human XCR1.
Clone RB31951
Isotype Ig
Specificity This XCR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 302-333 amino acids from the C-terminal region of human XCR1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name XCR1
Background The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms: XCR1,Chemokine XC receptor 1,CCXCR1, GPR5
Molecular Weight 38508 DA
Gene ID 2829
UniProt P46094, NP_005274.1
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.3 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Chemokine (C Motif) Receptor 1 (XCR1) (C-Term), (AA 305-333) antibody XCR1 Antibody (C-term) (ABIN655980) western blot analysis in MDA-MB435 cell line lysates (35 µg/lane). This demonstrates the XCR1 antibody detected the XCR1 protein (arrow).
Background publications Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Bachem, Güttler, Hartung et al.: "Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1273-81, 2010 (PubMed).

Crozat, Guiton, Contreras et al.: "The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1283-92, 2010 (PubMed).

Yamazaki, Miyamoto, Hoshino et al.: "Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice." in: Biochemical and biophysical research communications, Vol. 397, Issue 4, pp. 756-61, 2010 (PubMed).

Hosts (19), (4)
Reactivities (23)
Applications (15), (7), (6), (4), (2), (2), (2)
Conjugates (1), (1)
Epitopes (4), (2), (2), (2), (2), (2), (1), (1), (1)
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