Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2) (C-Term) antibody

Antigen: Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase 2 (TNKS2)

Synonyms: Tank2, AA517131, AI662480, 5430432P15Rik, TNKL, TANK2, PARP5B, PARP5C, PARP-5b, PARP-5c, TNKS2

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656002

Additional Information

Alternative name: Tnks2

Gene ID: 80351

UniProt: NP_079511.1, Q9H2K2

Immunogen: This Tnks2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1133-1164 amino acids from the C-terminal region of human Tnks2.

Isotype: Ig

Description: Other names: TNKS2,Tankyrase-2,PARP5B, TANK2, TNKL

Characteristics: Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This Tnks2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1133-1164 amino acids from the C-terminal region of human Tnks2.

Molecular Weight: 126918 DA

Comments:

Background: TNKS2 may regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TRF1, and thereby contribute to the regulation of telomere length.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Cell Structure, Protein Modifications, Chromatin, Signaling

Restrictions: For Research Use only

Images

Tnks2 Antibody (C-term) (ABIN656002) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Publications

Product: Varadi, Brendle, Brandt et al.: "Polymorphisms in telomere-associated genes, breast cancer susceptibility and prognosis." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 17, pp. 3008-16, 2009 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Prescott, McGrath, Lee et al.: "Telomere length and genetic analyses in population-based studies of endometrial cancer risk." in: Cancer, Vol. 116, Issue 18, pp. 4275-82, 2010 (PubMed).