Suppressor of Variegation 4-20 Homolog 1 (Drosophila) (SUV420H1) (C-Term) antibody

Antigen: Suppressor of Variegation 4-20 Homolog 1 (Drosophila) (SUV420H1)

Synonyms: CGI85, KMT5B, CGI-85, MGC703, MGC21161, MGC118906, MGC118909, AA117471, MGC18702, Suv4-20h1, C630029K18Rik, SUV420H1, wu:fb97g06, wu:fi57g03, zgc:103527, MGC137299

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656010

Additional Information

Alternative name: SUV4-20H1

Gene ID: 51111

UniProt: NP_060105.3, NP_057112.3, Q4FZB7

Immunogen: This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 766-797 amino acids from the C-terminal region of human SUV4-20H1.

Isotype: Ig

Description: Other names: SUV420H1,Histone-lysine N-methyltransferase SUV420H1,KMT5B

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 766-797 amino acids from the C-terminal region of human SUV4-20H1.

Molecular Weight: 99188 DA

Comments:

Background: This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Signaling, Protein Modifications, Transcription Factors, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

SUV4-20H1 Antibody (C-term) (ABIN656010) western blot analysis in HepG2 cell line lysates (35ug/lane). This demonstrates the SUV4-20H1 antibody detected the SUV4-20H1 protein (arrow).

Publications

Product: Yang, Pesavento, Starnes et al.: "Preferential dimethylation of histone H4 lysine 20 by Suv4-20." in: The Journal of biological chemistry, Vol. 283, Issue 18, pp. 12085-92, 2008 (PubMed).

Chinenov, Sacta, Cruz et al.: "GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 51, pp. 20185-90, 2008 (PubMed).