RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) (AA 787-816), (Center), (Thr802) antibody

Details for Product No. ABIN656017
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Antigen
Synonyms xBLM, recq2, recql2, recql3, AI846146, RECQ3, RECQL2, RECQL3
Epitope
AA 787-816, Center, Thr802
(8), (7), (6), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(36), (2), (1)
Host
Rabbit
(24), (14)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(34), (20), (10), (9), (8), (5), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN656017
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Immunogen This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 AA from the Central region of human WRN.
Clone RB17383
Isotype Ig
Specificity This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-825 amino acids from the Central region of human WRN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WRN
Background This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Synonyms: WRN,Werner syndrome ATP-dependent helicase,RECQ3, RECQL2
Molecular Weight 162495 DA
Gene ID 7486
NCBI Accession NP_000544
UniProt Q14191
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) (AA 787-816), (Center), (Thr802) antibody WRN Antibody (Center T802) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the WRN antibody detected the WRN protein (arrow).
anti-RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) (AA 787-816), (Center), (Thr802) antibody (2) WRN Antibody (Center T802) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications Perry, Asaithamby, Barnebey et al.: "Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25699-707, 2010 (PubMed).

Validation Images
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