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Details for Product No. ABIN656017

RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) (AA 787-816), (Center), (Thr802) antibody

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Antigen
Synonyms RECQ3, RECQL2, RECQL3, xBLM, recq2, recql2, recql3
Epitope
»Alternatives AA 787-816, Center, Thr802
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 1 reference available
Catalog no. ABIN656017
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 AA from the Central region of human WRN.
Clone RB17383
Isotype Ig
Specificity This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 794-825 amino acids from the Central region of human WRN.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WRN
Background This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
Synonyms: WRN,Werner syndrome ATP-dependent helicase,RECQ3, RECQL2
Molecular Weight 162495 DA
Gene ID 7486
UniProt NP_000544.2, Q14191
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Perry, Asaithamby, Barnebey et al.: "Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25699-707, 2010 (PubMed).

Alternatives for antigen "RECQL2 (ARABIDOPSIS RECQ HELICASE L2), 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2)", type "Antibodies"
Hosts (17), (8)
Reactivities (23), (1)
Applications (22), (8), (8), (3), (3), (2), (1), (1), (1)
Epitopes (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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