Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (AA 1078-1105), (C-Term) antibody

Details for Product No. ABIN656023, Supplier: Log in to see
Antigen
  • ZFHX1B
  • zfhx1b
  • XSip1
  • sip1
  • HSPC082
  • SIP-1
  • SIP1
  • SMADIP1
  • ZEB2
  • 9130203F04Rik
  • D130016B08Rik
  • Zfhx1b
  • Zfx1b
  • Zfxh1b
  • mKIAA0569
  • si:dkey-52o2.2
  • sip1a
  • wu:fc92g08
  • sip1b
  • zinc finger E-box binding homeobox 2
  • zinc finger homeobox protein
  • zinc finger E-box binding homeobox 2a
  • zinc finger E-box binding homeobox 2b
  • ZEB2
  • LOC100220433
  • zeb2
  • Zeb2
  • zeb2a
  • zeb2b
Alternatives
anti-Human Zinc Finger E-Box Binding Homeobox 2 antibody for ELISA
Epitope
AA 1078-1105, C-Term
24
12
12
10
9
9
8
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
127
43
37
12
9
9
8
7
5
5
4
4
2
2
1
1
Host
Rabbit
82
29
17
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
110
61
31
28
26
11
8
5
5
2
Options
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Immunogen This ZEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1078-1105 AA from the C-terminal region of human ZEB2.
Clone RB19137
Isotype Ig
Specificity This ZEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1085-1113 amino acids from the C-terminal region of human ZEB2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ZEB2 (ZEB2 Antibody Abstract)
Background The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
Synonyms: ZEB2,Zinc finger E-box-binding homeobox 2,KIAA0569, SIP1, ZFHX1B, ZFX1B
Molecular Weight 136447 DA
Gene ID 9839
NCBI Accession NP_001165124, NP_055610
UniProt O60315
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Neurology, Cell Structure
Pathways Tube Formation
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Flow Cytometry (FACS) image for anti-Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (AA 1078-1105), (C-Term) antibody (ABIN656023) ZEB2 Antibody (C-term) (ABIN656023) flow cytometric analysis of MDA-MB435 cells (righ...
Background publications Kumar, Kotlyarevska, Dejkhmaron, Reddy, Lu, Bhojani, Menon et al.: "Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for ..." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31148-56, 2010 (PubMed).

Li, Omura, Hong, Vincent, Walter, Griffith, Borges, Goggins: "Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels." in: Cancer research, Vol. 70, Issue 13, pp. 5226-37, 2010 (PubMed).

Ohashi, Natsuizaka, Wong, Michaylira, Grugan, Stairs, Kalabis, Vega, Kalman, Nakagawa, Klein-Szanto, Herlyn, Diehl, Rustgi, Nakagawa: "Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors." in: Cancer research, Vol. 70, Issue 10, pp. 4174-84, 2010 (PubMed).