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Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Center, Tyr224) antibody

Antigen

Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)
Synonyms CAS, CAS1, CASS1, CRKAS, P130Cas, Cas, Crkas, AI385681, P130CAS, MGC68466, cas, p130cas, BCAR1, bcar1, fc17f11, MGC175192, wu:fc17f11
Binding Site
Alternatives

Center, Tyr224
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN656134
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Breast Cancer Anti-Estrogen Resistance 1 (BCAR1) (Center, Tyr224) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name p130cas
Gene ID 9564
UniProt P56945, NP_055382
Immunogen This p130cas antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human p130cas.
Isotype Ig
Description Other names: BCAR1,Breast cancer anti-estrogen resistance protein 1,CAS, CASS1, CRKAS
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This p130cas antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the Central region of human p130cas.
Molecular Weight 93372 DA
Comments

Background: BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage p130cas Antibody (Center Y224) can be refrigerated at 2-8°C for up to 6 months. For long term storage, place the at -20°C.
Research Area Signaling, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Restrictions For Research Use only

Publications
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Product Qian, Li, Vass et al.: "The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis." in: Cancer cell, Vol. 16, Issue 3, pp. 246-58, 2009 (PubMed).

Wendt, Smith, Schiemann: "p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity." in: The Journal of biological chemistry, Vol. 284, Issue 49, pp. 34145-56, 2009 (PubMed).

Schuh, Guerrero, Schrecengost et al.: "BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2309-17, 2010 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Breast Cancer Anti-Estrogen Resistance 1 (BCAR1)", type "Antibodies"
Hosts Rabbit (52), Mouse (12), Sheep (1)
Reactivities Human (61), Rat (Rattus) (49), Mouse (Murine) (42), Dog (Canine) (23), Cow (Bovine) (19), Horse (Equine) (5), Monkey (4), Cat (Feline) (1), Chicken (1)
Applications Western Blotting (WB) (35), Immunofluorescence (IF) (33), ELISA (20), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunoprecipitation (IP) (11), Flow Cytometry (FACS) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr410 (6), C-Term (5), pTyr165 (5), AA 949-968 (2), Internal Region (2), AA 66-412 (1), AA 670-896 (1), AA 691-799 (1), C-Term,pSer639 (1), pSer2481 (1), pTyr234 (1), pTyr249 (1)