Karyopherin alpha 6 (Importin alpha 7) (KPNA6) (C-Term) antibody

Antigen: Karyopherin alpha 6 (Importin alpha 7) (KPNA6)

Synonyms: IPOA7, KPNA7, FLJ11249, MGC17918

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656162

Additional Information

Alternative name: KPNA6

Gene ID: 23633

UniProt: O60684, NP_036448.1

Immunogen: This KPNA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-467 amino acids from the C-terminal region of human KPNA6.

Isotype: Ig

Description: Other names: KPNA6,Importin subunit alpha-7,IPOA7

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This KPNA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-467 amino acids from the C-terminal region of human KPNA6.

Molecular Weight: 60030 DA

Comments:

Background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: KPNA6 Antibody (C-term) can be refrigerated at 2-8°C for up to 6 months. For long term storage, place the at -20°C.

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

KPNA6 Antibody (C-term) (ABIN656162) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KPNA6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Bouwmeester, Bauch, Ruffner et al.: "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway." in: Nature cell biology, Vol. 6, Issue 2, pp. 97-105, 2004 (PubMed).