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RHOB (AA 104-137), (Center) antibody

Details for Product No. ABIN656198, Supplier: Log in to see
Antigen
  • ARH6
  • ARHB
  • MST081
  • MSTP081
  • RHOH6
  • Arhb
  • RHO
  • AA017882
  • Arh6
Epitope
AA 104-137, Center
6
4
3
3
2
1
1
1
1
1
Reactivity
Human
45
19
17
Host
Rabbit
37
6
3
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
39
14
14
7
3
2
1
1
1
Supplier
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Immunogen This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-137 AA from the Central region of human ARHB.
Clone RB14498
Isotype Ig
Specificity This ARHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-137 amino acids from the Central region of human ARHB.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ARHB
Background ARHB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development.
Synonyms: RHOB,Rho-related GTP-binding protein RhoB,ARH6, ARHB
Molecular Weight 22123 DA
Gene ID 388
NCBI Accession NP_004031
UniProt P62745
Research Area Apoptosis/Necrosis, Translation Factors, Signaling, Phospho-specific antibodies, Cell Structure, Protein Modifications, Cancer, Cell Cycle, Chromatin
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ARHB Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-RHOB (AA 104-137), (Center) antibody (ABIN656198) ARHB Antibody (Center) (ABIN656198) immunohistochemistry analysis in formalin fixed a...
Background publications Connolly, Van Doorslaer, Rogler et al.: "Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB." in: Molecular cancer research : MCR, Vol. 8, Issue 5, pp. 691-700, 2010 (PubMed).

Takefuji, Asano, Mori et al.: "Mutation of ARHGAP9 in patients with coronary spastic angina." in: Journal of human genetics, Vol. 55, Issue 1, pp. 42-9, 2010 (PubMed).

Adly, Assaf, Hussein: "Expression of Ras homologous B protein in the human scalp skin and hair follicles: hair follicle cycle stages-associated changes." in: Journal of cutaneous pathology, Vol. 37, Issue 7, pp. 751-7, 2010 (PubMed).