SCAP (N-Term), (AA 54-83) antibody

Details for Product No. ABIN656233
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Antigen
Synonyms 9530044G19, mKIAA0199
Epitope
N-Term, AA 54-83
(8), (8), (6), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(36), (14), (14), (12), (12), (12)
Host
Rabbit
(36)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(27), (16), (11), (10), (10), (6), (3), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN656233
291.50 $
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Immunogen This SCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 AA from the N-terminal region of human SCAP.
Clone RB31071
Isotype Ig
Specificity This SCAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-83 amino acids from the N-terminal region of human SCAP.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis.
Synonyms: SCAP,Sterol regulatory element-binding protein cleavage-activating protein,KIAA0199
Molecular Weight 139729 DA
Gene ID 22937
NCBI Accession NP_036367
UniProt Q12770
Research Area Phospho-specific antibodies, Cell Structure, Protein Modifications, Metabolism
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.28 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SCAP Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-SCAP (N-Term), (AA 54-83) antibody SCAP Antibody (N-term) (ABIN656233) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications McGeachie, Ramoni, Mychaleckyj et al.: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009 (PubMed).

Voora, Shah, Reed et al.: "Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response." in: Circulation. Cardiovascular genetics, Vol. 1, Issue 2, pp. 100-6, 2009 (PubMed).

Vasseur, Caeyseele, Barat-Houari et al.: "Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population." in: Journal of human genetics, Vol. 55, Issue 4, pp. 227-31, 2010 (PubMed).

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