Calpain 6 antibody (AA 390-419)

Catalog No. ABIN656477

Product Details anti-Calpain 6 Antibody

Target: Calpain 6 (CAPN6)

Binding Specificity: AA 390-419

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CAPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-419 amino acids from the Central region of human CAPN6.

Clone: RB19561

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: CAPN6 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for Calpain 6

Target: Calpain 6 (CAPN6)

Alternative Name: CAPN6 (CAPN6 Products)

Synonyms: CAPN6 antibody, CANPX antibody, CAPNX antibody, CalpM antibody, DJ914P14.1 antibody, calpain 6 antibody, CAPN6 antibody, Capn6 antibody

Background: Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Molecular Weight: 74576

Gene ID: 827

NCBI Accession: NP_055104

UniProt: Q9Y6Q1