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Details for Product No. ABIN656492

Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) (C-Term), (AA 214-243) antibody

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Antigen
Synonyms FCNH, HAKA1
Epitope
»Alternatives C-Term, AA 214-243
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN656492
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-243 AA from the C-terminal region of human FCN3.
Clone RB31101
Isotype Ig
Specificity This FCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 213-243 amino acids from the C-terminal region of human FCN3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FCN3
Background Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.
Synonyms: Ficolin-3,FCN3,FCNH, HAKA1
Molecular Weight 32903 DA
Gene ID 8547
UniProt O75636, NP_775628.1, NP_003656.2
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.27 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment FCN3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Munthe-Fog, Hummelshøj, Ma et al.: "Characterization of a polymorphism in the coding sequence of FCN3 resulting in a Ficolin-3 (Hakata antigen) deficiency state." in: Molecular immunology, Vol. 45, Issue 9, pp. 2660-6, 2008 (PubMed).

Lacroix, Dumestre-Pérard, Schoehn et al.: "Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 1, pp. 456-65, 2008 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Alternatives for antigen "Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3)", type "Antibodies"
Hosts (10), (4)
Reactivities (13)
Applications (12), (7), (2), (2), (2), (2), (1), (1)
Epitopes (4), (3), (2), (2), (1)
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