MOB1A antibody (N-Term)

Catalog No. ABIN656811

Product Details anti-MOB1A Antibody

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Binding Specificity: AA 5-33, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOB1A antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MOBKL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human MOBKL1B.

Clone: RB19209

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MOBKL1B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

Target Details for MOB1A

Target: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Alternative Name: MOBKL1B (MOBKL1B Products)

Synonyms: mob1 antibody, mob4b antibody, MOB1A antibody, MOBK1B antibody, MOB1 antibody, mats1 antibody, mobk1b antibody, mobkl1b antibody, MOBKL1B antibody, wu:fv69d04 antibody, zgc:56189 antibody, C2orf6 antibody, MATS1 antibody, Mob4B antibody, 4022402H07Rik antibody, MOB4B antibody, Mobk1b antibody, Mobkl1b antibody, MOB kinase activator 1A L homeolog antibody, MOB kinase activator 1A antibody, MOB kinase activator 1A pseudogene antibody, mob1a.L antibody, MOB1A antibody, mob1a antibody, LOC712156 antibody, Mob1a antibody

Background: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.

Molecular Weight: 25080

Gene ID: 55233

NCBI Accession: NP_060691

UniProt: Q9H8S9