CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) (N-Term), (AA 33-60) antibody

Details for Product No. ABIN656816
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Antigen
Synonyms CAF1, CALIF, Caf1b, POP2, hCAF1, AA536816, AU015770, AU043059, 1500015I04Rik, 1810022F04Rik, calif, pop2, zgc:63844, wu:fe49a05, caf1, hcaf1
Epitope
N-Term, AA 33-60
(6), (6), (2), (2), (2), (2), (1)
Reactivity
Human
(27), (18), (14), (12)
Host
Rabbit
(27), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(18), (10), (7), (6), (5), (4), (3), (2), (2)
Pubmed 5 references available
Catalog no. ABIN656816
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 AA from the N-terminal region of human CNOT8.
Clone RB19574
Isotype Ig
Specificity This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-60 amino acids from the N-terminal region of human CNOT8.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CNOT8
Background Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex.
Synonyms: CCR4-NOT transcription complex subunit 8,CNOT8,CALIF, POP2
Molecular Weight 33540 DA
Gene ID 9337
UniProt NP_004770.4, Q9UFF9
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment CNOT8 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) (N-Term), (AA 33-60) antibody Western blot analysis of CNOT8 (arrow) using rabbit polyclonal CNOT8 Antibody (N-term) (ABIN656816). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CNOT8 gene.
Background publications Lau, Kolkman, van Schaik et al.: "Human Ccr4-Not complexes contain variable deadenylase subunits." in: The Biochemical journal, Vol. 422, Issue 3, pp. 443-53, 2009 (PubMed).

Aslam, Mittal, Koch et al.: "The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation." in: Molecular biology of the cell, Vol. 20, Issue 17, pp. 3840-50, 2009 (PubMed).

Piao, Zhang, Wu et al.: "CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1486-94, 2010 (PubMed).

Marchese, Aubareda, Tudor et al.: "MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27590-600, 2010 (PubMed).

Ruan, Osawa, Hosoda et al.: "Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27624-31, 2010 (PubMed).

Hosts (27), (2)
Reactivities (27), (18), (14), (12)
Applications (18), (10), (7), (6), (5), (4), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (6), (2), (2), (2), (2), (1)
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