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Details for Product No. ABIN656896

Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2) (N-Term), (AA 15-44) antibody

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Antigen
Synonyms 9630032G22Rik, AI662535, LRRGT00063, BRESEK, IFAP, KFSDX, S2P
Epitope
»Alternatives N-Term, AA 15-44
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN656896
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 AA from the N-terminal region of human MBTPS2.
Clone RB32439
Isotype Ig
Specificity This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human MBTPS2.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MBTPS2
Background This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
Synonyms: Membrane-bound transcription factor site-2 protease,MBTPS2,S2P
Molecular Weight 57444 DA
Gene ID 51360
UniProt NP_056968.1, O43462
Research Area Protein Modifications, Cell Structure, Metabolism
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MBTPS2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Lee, Tirasophon, Shen et al.: "IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response." in: Genes & development, Vol. 16, Issue 4, pp. 452-66, 2002 (PubMed).

Alternatives for antigen "Membrane-Bound Transcription Factor Peptidase, Site 2 (MBTPS2)", type "Antibodies"
Hosts (8), (1)
Reactivities (9), (4), (4)
Applications (7), (6), (4), (2), (2)
Epitopes (3), (2), (1), (1), (1)
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