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Histone Cluster 1, H2ab (HIST1H2AB) (AA 12-40), (N-Term) antibody

Details for Product No. ABIN656986, Supplier: Log in to see
Antigen
  • H2a-53
  • H2A.1
  • H2A/m
  • H2AFM
Alternatives
anti-Human Histone Cluster 1, H2ab antibody for Flow Cytometry
Epitope
AA 12-40, N-Term
35
14
14
5
3
2
1
Reactivity
Human
46
4
4
Host
Rabbit
46
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
5
4
4
4
4
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
38
35
20
15
1
1
1
Supplier
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Immunogen This HIST1H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 AA from the N-terminal region of human HIST1H2AB.
Clone RB32983
Isotype Ig
Specificity This HIST1H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-40 amino acids from the N-terminal region of human HIST1H2AB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HIST1H2AB (HIST1H2AB Antibody Abstract)
Background Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails, instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
Synonyms: Histone H2A type 1-B/E,HIST1H2AB,H2AFM
Molecular Weight 14135 DA
Gene ID 8335, 3012
NCBI Accession NP_066390, NP_003504
UniProt P04908
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways Telomere Maintenance
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HIST1H2AB Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Histone Cluster 1, H2ab (HIST1H2AB) (AA 12-40), (N-Term) antibody (ABIN656986) HIST1H2AB Antibody (N-term) (ABIN656986) immunohistochemistry analysis in formalin fi...
Background publications Cao, Tsukada, Zhang: "Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing." in: Molecular cell, Vol. 20, Issue 6, pp. 845-54, 2005 (PubMed).

Hagiwara, Hidaka, Yamada: "Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes." in: Biochemistry, Vol. 44, Issue 15, pp. 5827-34, 2005 (PubMed).

Andersen, Lam, Leung, Ong, Lyon, Lamond, Mann: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, 2005 (PubMed).