PRCP antibody (N-Term)

Catalog No. ABIN657308

Product Details anti-PRCP Antibody

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Binding Specificity: AA 114-143, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRCP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP.

Clone: RB32742

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PRCP

Target: PRCP (Prolylcarboxypeptidase (PRCP))

Alternative Name: PRCP (PRCP Products)

Synonyms: OI13 antibody, PCOLC antibody, PCP antibody, PCP2 antibody, TLD antibody, humpcp antibody, MGC145178 antibody, 2510048K03Rik antibody, 2610104A14Rik antibody, AI451719 antibody, HUMPCP antibody, zgc:91816 antibody, bone morphogenetic protein 1 antibody, prolylcarboxypeptidase antibody, lysosomal Pro-X carboxypeptidase antibody, prolylcarboxypeptidase (angiotensinase C) antibody, BMP1 antibody, prcp antibody, LOC5579822 antibody, CpipJ_CPIJ006123 antibody, CpipJ_CPIJ006124 antibody, Prcp antibody, PRCP antibody

Background: The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH , but the enzyme activity is retained with some substrates at neutral pH . This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].

Molecular Weight: 55800

NCBI Accession: NP_005031, NP_955450

UniProt: P42785