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Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (AA 509-536), (Center) antibody

Details for Product No. ABIN657549, Supplier: Log in to see
Antigen
  • AIF4
  • AIP4
  • NAPP1
  • dJ468O1.1
  • 6720481N21Rik
  • 8030492O04Rik
  • A130065M08
  • C230047C07Rik
Epitope
AA 509-536, Center
27
16
9
9
5
5
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
54
34
7
3
2
1
1
1
Host
Rabbit
45
15
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
4
3
3
3
3
Application
Western Blotting (WB)
49
49
8
6
2
1
1
Supplier
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Immunogen This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 AA from the Central region of human ITCH.
Clone RB33154
Isotype Ig
Specificity This ITCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-536 amino acids from the Central region of human ITCH.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ITCH (ITCH Antibody Abstract)
Background Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Synonyms: E3 ubiquitin-protein ligase Itchy homolog,ITCH,
Molecular Weight 102803 DA
Gene ID 83737
NCBI Accession NP_113671
UniProt Q96J02
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ITCH Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Itchy E3 Ubiquitin Protein Ligase Homolog (Mouse) (ITCH) (AA 509-536), (Center) antibody (ABIN657549) ITCH Antibody (Center) (ABIN657549) western blot analysis in mouse brain tissue lysat...
Background publications Lohr, Molleston, Strauss et al.: "Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease." in: American journal of human genetics, Vol. 86, Issue 3, pp. 447-53, 2010 (PubMed).