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Amyloid beta (A4) Precursor Protein (APP) (AA 333-362), (Center) antibody

Details for Product No. ABIN657612, Supplier: Login to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
Alternatives
anti-Human Amyloid beta (A4) Precursor Protein antibody for Enzyme Immunoassay
Epitope
AA 333-362, Center
122
109
52
35
25
20
19
17
17
15
15
14
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14
13
10
10
8
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5
5
5
5
5
5
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4
4
4
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
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1
1
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1
1
1
1
1
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1
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1
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1
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1
1
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1
Reactivity
Human
823
308
277
41
11
9
8
8
6
3
2
2
1
1
1
1
Host
Rabbit
579
223
50
3
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
48
37
35
17
13
13
13
13
13
13
13
13
12
11
11
2
2
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
563
316
231
149
147
74
57
33
29
20
15
10
9
8
6
3
2
2
2
2
1
Supplier
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Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 AA from the Central region of human APP.
Clone RB33592
Isotype Ig
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name APP (APP Antibody Abstract)
Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms: Amyloid beta A4 protein,APP,A4, AD1
Molecular Weight 79kd Isoform. 86943 DA
Gene ID 351
NCBI Accession NP_001129601, NP_958816, NP_001129602, NP_000475
UniProt P05067
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway
Application Notes WB = 1:1000, IF = 1:10-50, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment APP Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 333-362), (Center) antibody (ABIN657612) APP Antibody (Center) (ABIN657612) western blot analysis in 293 cell line lysates (35...
Background publications Crews, Adame, Patrick et al.: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, 2010 (PubMed).

Singh, Park, Bae et al.: "MEGF10 functions as a receptor for the uptake of amyloid-β." in: FEBS letters, Vol. 584, Issue 18, pp. 3936-42, 2010 (PubMed).