MMP16 antibody (C-Term)

Catalog No. ABIN657636

Product Details anti-MMP16 Antibody

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Binding Specificity: AA 519-548, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP16 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MMP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 519-548 amino acids from the C-terminal region of human MMP16.

Clone: RB33657

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MMP16 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-MMP16 antibody (ABIN657636)

Wu, Ma, Shan, Zhou, Li: "High expression of matrix metalloproteinases 16 is associated with the aggressive malignant behavior and poor survival outcome in colorectal carcinoma." in: Scientific reports, Vol. 7, pp. 46531, (2017) (PubMed).

Shen, Wang, Yu, Zhang, Qin: "MMP16 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma." in: Oncotarget, Vol. 8, Issue 42, pp. 72197-72204, (2017) (PubMed).

Target Details for MMP16

Target: MMP16 (Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16))

Alternative Name: MMP16 (MMP16 Products)

Synonyms: MT3-MMP antibody, Mt3mmp antibody, Mt3-mmp antibody, C8orf57 antibody, MMP-X2 antibody, MT-MMP2 antibody, MT-MMP3 antibody, matrix metallopeptidase 16 antibody, Mmp16 antibody, MMP16 antibody

Background: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Molecular Weight: 69521

Gene ID: 4325

NCBI Accession: NP_005932

UniProt: P51512