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CD27 antibody (CD27 Molecule) (AA 196-225)

Details for Product anti-CD27 Antibody No. ABIN657662, Supplier: Log in to see
Antigen
  • S152
  • S152. LPFS2
  • T14
  • Tnfrsf7
  • TNFRSF7
  • Tp55
Epitope
AA 196-225, C-Term
18
15
13
8
8
7
6
6
6
3
2
2
2
1
1
1
1
Reactivity
Human
419
168
69
4
4
4
2
1
Host
Rabbit
263
82
69
45
29
2
Clonality (Clone)
Polyclonal ()
Conjugate
This CD27 antibody is un-conjugated
52
50
31
25
12
12
12
10
10
8
7
7
6
6
6
6
6
6
6
6
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
402
66
65
55
42
39
25
24
21
11
8
6
2
2
2
2
1
1
1
1
Supplier
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Immunogen This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-225 AA from the C-terminal region of human CD27.
Clone RB33726
Isotype Ig
Specificity This CD27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-225 amino acids from the C-terminal region of human CD27.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CD27 (CD27 Antibody Abstract)
Background The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
Synonyms: CD27 antigen,CD27,TNFRSF7
Molecular Weight 29137 DA
Gene ID 939
NCBI Accession NP_001233
UniProt P26842
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CD27 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CD27 antibody (CD27 Molecule) (AA 196-225) (ABIN657662) Western blot analysis of CD27 (arrow) using rabbit polyclonal CD27 Antibody (C-term) ...
Background publications Arimoto-Miyamoto, Kadowaki, Kitawaki, Iwata, Morimoto, Uchiyama: "Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4(+) T-cell differentiation." in: Immunology, Vol. 130, Issue 1, pp. 137-49, 2010 (PubMed).

Mizuochi, Ito, Saito, Kasai, Kunimura, Morohoshi, Momose, Hamaguchi, Takai, Iino, Suzuki, Mochida, Ikebuchi, Yamaguchi: "Possible recruitment of peripheral blood CXCR3+ CD27+ CD19+ B cells to the liver of chronic hepatitis C patients." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 30, Issue 4, pp. 243-52, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).