MEN1 (N-Term) antibody

Antigen: MEN1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657669

Additional Information

Gene ID: 4221

UniProt: NP_000235.2, NP_570716.1, NP_570711.1, O00255, NP_570712.1

Immunogen: This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human MEN1.

Isotype: Ig

Description: Other names: Menin,MEN1,SCG2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human MEN1.

Molecular Weight: 67993 DA

Comments:

Background: This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: MEN1 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

MEN1 Antibody (N-term) (ABIN657669) western blot analysis in CEM cell line lysates (35ug/lane). This demonstrates the MEN1 antibody detected the MEN1 protein (arrow).

Publications

Product: Stratakis, Tichomirowa, Boikos et al.: "The role of germline AIP, MEN1, PRKAR1A, CDKN1B and CDKN2C mutations in causing pituitary adenomas in a large cohort of children, adolescents, and patients with genetic syndromes." in: Clinical genetics, Vol. 78, Issue 5, pp. 457-63, 2010 (PubMed).