You are viewing an incomplete version of our website. Please click to reload the website as full version.

Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (AA 17-45)

Details for Product anti-CASP6 Antibody No. ABIN657756, Supplier: Log in to see
Antigen
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
  • caspase 6, apoptosis-related cysteine peptidase
  • caspase 6
  • caspase-6
  • Caspase-6
  • caspase-6-like
  • casp6
  • CASP6
  • CpipJ_CPIJ017008
  • Casp6
  • LOC100341546
  • LOC100517293
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 17-45, N-Term
47
40
37
16
15
14
14
13
11
6
5
5
5
5
5
5
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
284
117
105
16
5
5
5
3
2
1
Host
Rabbit
274
21
17
Clonality (Clone)
Polyclonal ()
Conjugate
This Caspase 6 antibody is un-conjugated
18
17
13
10
10
10
3
3
3
3
3
3
3
3
3
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
267
147
121
61
38
31
25
19
8
5
5
5
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 AA from the N-terminal region of human CASP6.
Clone RB33636
Isotype Ig
Specificity This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CASP6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP6 (CASP6 Antibody Abstract)
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq].
Synonyms: Caspase-6,CASP6,MCH2
Molecular Weight 33310 DA
Gene ID 839
NCBI Accession NP_001217, NP_116787
UniProt P55212
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CASP6 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (AA 17-45) (ABIN657756) Western blot analysis of CASP6 (arrow) using rabbit polyclonal CASP6 Antibody (N-term...
Background publications Würstle, Laussmann, Rehm: "The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33209-18, 2010 (PubMed).

Lee, Choi, Choi, Kim, Kim, Jung, Kang, Jeon, Lee, Jin, Cha, Kim, Jung, Park: "Polymorphisms in the caspase genes and the risk of lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1152-8, 2010 (PubMed).

Halawani, Tessier, Anzellotti, Bennett, Latterich, LeBlanc: "Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 17, pp. 6132-42, 2010 (PubMed).