Activin Receptor Type I (ACRV1) (Center) antibody

Antigen: Activin Receptor Type I (ACRV1)

Synonyms: ALK2, Acvr, Alk8, SKR1, Alk-2, Tsk7L, ActR-I, ActRIA, Acvrlk2, D330013D15Rik, ActR-IA

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657777

Additional Information

Alternative name: ACVR1

Gene ID: 90

UniProt: Q04771, NP_001104537.1, NP_001096.1

Immunogen: This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-161 amino acids from the Central region of human ACVR1.

Isotype: Ig

Description: Other names: Activin receptor type-1,ACVR1,ACVRLK2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ACVR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-161 amino acids from the Central region of human ACVR1.

Molecular Weight: 57153 DA

Comments:

Background: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: ACVR1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling

Restrictions: For Research Use only

Images

Western blot analysis of ACVR1 (arrow) using rabbit polyclonal ACVR1 Antibody (Center) (ABIN657777). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ACVR1 gene.

Publications

Product: Herrera, van Dinther, Ten Dijke et al.: "Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation." in: Cancer research, Vol. 69, Issue 24, pp. 9254-62, 2009 (PubMed).

Song, Kim, Woo et al.: "Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22542-53, 2010 (PubMed).

Canzian, Cox, Setiawan et al.: "Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium." in: Human molecular genetics, Vol. 19, Issue 19, pp. 3873-84, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).