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TRF2 antibody (Telomeric Repeat Binding Factor 2) (AA 308-337)

Details for Product anti-TERF2 Antibody No. ABIN657781, Supplier: Log in to see
Antigen
  • TERF2
  • TRBF2
  • TRF2
  • trf2
Alternatives
anti-Human TRF2 antibody for Immunohistochemistry (Frozen Sections)
Epitope
AA 308-337, Center
13
10
9
8
3
3
2
2
2
1
1
1
1
Reactivity
Human
68
17
9
3
3
2
1
Host
Rabbit
50
11
10
Clonality (Clone)
Polyclonal ()
Conjugate
This TRF2 antibody is un-conjugated
2
2
2
2
2
2
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
58
27
20
12
8
8
6
4
3
3
2
2
1
1
Supplier
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Immunogen This TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 AA from the Central region of human TERF2.
Clone RB33900
Isotype Ig
Specificity This TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-337 amino acids from the Central region of human TERF2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TERF2 (TERF2 Antibody Abstract)
Background This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.
Synonyms: Telomeric repeat-binding factor 2,TERF2,TRBF2, TRF2
Molecular Weight 55551 DA
Gene ID 7014
NCBI Accession NP_005643
UniProt Q15554
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Pathways Cell Division Cycle, Telomere Maintenance
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TERF2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TRF2 antibody (Telomeric Repeat Binding Factor 2) (AA 308-337) (ABIN657781) TERF2 Antibody (Center) (ABIN657781) western blot analysis in ZR-75-1 cell line lysat...
Background publications Ye, Lenain, Bauwens et al.: "TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage." in: Cell, Vol. 142, Issue 2, pp. 230-42, 2010 (PubMed).

Prescott, McGrath, Lee et al.: "Telomere length and genetic analyses in population-based studies of endometrial cancer risk." in: Cancer, Vol. 116, Issue 18, pp. 4275-82, 2010 (PubMed).

Bombarde, Boby, Gomez et al.: "TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends." in: The EMBO journal, Vol. 29, Issue 9, pp. 1573-84, 2010 (PubMed).