|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cyclin-Dependent Kinase 9 (CDK9) (C-Term) antibody
|Synonyms||TAK, C-2k, CTK1, CDC2L4, PITALRE, CDK9, P-TEF, P-TEFb, PTefb, DmelCG5179, CG5179, wu:fb22e09, wu:fc06c02, MGC95175, cdk9, MGC53831, MGC139578, tak, c-2k, cdc2l4, pitalre, MGC69296|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This CDK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-282 amino acids from the C-terminal region of human CDK9.|
|Description||Other names: Cell division protein kinase 9,CDK9,CDC2L4|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CDK9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-282 amino acids from the C-terminal region of human CDK9.|
|Molecular Weight||42778 DA|
Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||CDK9 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Pirngruber, Johnsen: "Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9." in: Oncogene, Vol. 29, Issue 19, pp. 2853-63, 2010 (PubMed).
Dow, Liu, Rice: "T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes." in: Journal of cellular physiology, Vol. 224, Issue 1, pp. 84-93, 2010 (PubMed).
Liu, Herrmann, Chiang et al.: "55K isoform of CDK9 associates with Ku70 and is involved in DNA repair." in: Biochemical and biophysical research communications, Vol. 397, Issue 2, pp. 245-50, 2010 (PubMed).