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Tyrosine-protein kinase ABL1 (ABL1) (AA 613-641), (Center) antibody

Details for Product No. ABIN657828, Supplier: Log in to see
Antigen
Epitope
AA 613-641, Center
51
50
40
30
29
27
25
23
16
15
15
15
14
14
14
14
14
14
14
14
12
9
8
8
8
7
7
7
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
591
338
271
9
3
1
Host
Rabbit
587
23
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
32
31
30
30
16
16
16
15
15
15
15
15
15
15
15
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
342
192
180
172
94
62
45
21
20
6
2
2
1
Supplier
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Immunogen This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 613-641 AA from the Central region of mouse Abl1.
Clone RB34442
Isotype Ig
Specificity This Mouse Abl1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 612-642 amino acids from the Central region of human Mouse Abl1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Abl1
Background Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Synonyms: Tyrosine-protein kinase ABL1,Abl1,Abl
Molecular Weight 122673 DA
Gene ID 11350
NCBI Accession NP_001106174, NP_033724
UniProt P00520
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cancer, Chromatin, Signaling
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.43 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Mouse Abl1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Tyrosine-protein kinase ABL1 (ABL1) (AA 613-641), (Center) antibody (ABIN657828) Mouse Abl1 Antibody (Center) (ABIN657828) western blot analysis in mouse spleen tissu...
Background publications Ko, Lee, Shin, Karuppagounder, Gadad, Koleske, Pletnikova, Troncoso, Dawson, Dawson: "Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 38, pp. 16691-6, 2010 (PubMed).

Perez de Arce, de Arce, Varela-Nallar, Farias, Cifuentes, Bull, Couch, Koleske, Inestrosa, Alvarez: "Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 10, pp. 3728-38, 2010 (PubMed).