Wingless-Type MMTV Integration Site Family, Member 8B (WNT8B) (C-Term), (AA 323-351) antibody

Details for Product No. ABIN657869
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Antigen
Synonyms WNT8B, wnt-8b, xwnt-8b, xwnt8b
Epitope
C-Term, AA 323-351
(16), (7), (4), (2), (1), (1), (1)
Reactivity
Human
(32), (18), (13), (12), (4), (1), (1), (1), (1)
Host
Rabbit
(36), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(25), (10), (10), (8), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN657869
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Immunogen This WNT8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 AA from the C-terminal region of human WNT8B.
Clone RB22565
Isotype Ig
Specificity This WNT8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-351 amino acids from the C-terminal region of human WNT8B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WNT8B
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Synonyms: Protein Wnt-8b,7479,
Molecular Weight 38721 DA
Gene ID 7479
NCBI Accession NP_003384
UniProt Q93098
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment WNT8B Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Wingless-Type MMTV Integration Site Family, Member 8B (WNT8B) (C-Term), (AA 323-351) antibody WNT8B Antibody (C-term) (ABIN657869) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the WNT8B antibody detected the WNT8B protein (arrow).
Background publications Saitoh, Mine, Katoh: "Up-regulation of WNT8B mRNA in human gastric cancer." in: International journal of oncology, Vol. 20, Issue 2, pp. 343-8, 2002 (PubMed).

Saitoh, Mine, Katoh: "Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells." in: International journal of oncology, Vol. 20, Issue 5, pp. 999-1003, 2002 (PubMed).

Deloukas, Earthrowl, Grafham et al.: "The DNA sequence and comparative analysis of human chromosome 10." in: Nature, Vol. 429, Issue 6990, pp. 375-81, 2004 (PubMed).

Grupe, Li, Rowland et al.: "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease." in: American journal of human genetics, Vol. 78, Issue 1, pp. 78-88, 2005 (PubMed).

Katoh, Katoh: "Conserved POU/OCT- and GATA-binding sites in 5'-flanking promoter region of mammalian WNT8B orthologs." in: International journal of oncology, Vol. 30, Issue 5, pp. 1273-7, 2007 (PubMed).

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