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Details for Product No. ABIN657904

Laminin, beta 1 (LAMB1) (C-Term), (AA 1691-1720) antibody

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Antigen
Synonyms CLM, LIS5, Lamb1-1, C77966, C80098, C81607, D130003D08Rik, Lamb-1, fc20b05, gup, lamb1, sb:cb95, wu:fc20b05, LAMB1, lams
Epitope
»Alternatives C-Term, AA 1691-1720
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN657904
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This LAMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1691-1720 AA from the C-terminal region of human LAMB1.
Clone RB33607
Isotype Ig
Specificity This LAMB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1690-1720 amino acids from the C-terminal region of human LAMB1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LAMB1
Background Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
Synonyms: Laminin subunit beta-1,3912,
Molecular Weight 198066 DA
Gene ID 3912
UniProt NP_002282.2, P07942
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment LAMB1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Rooney, Gurpur, Burkin: "Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 7991-6, 2009 (PubMed).

Wheeler, Metter, Tanaka et al.: "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging." in: PLoS genetics, Vol. 5, Issue 10, pp. e1000685, 2009 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Alternatives for antigen "Laminin, beta 1 (LAMB1)", type "Antibodies"
Hosts (34), (21), (12)
Reactivities (52), (36), (13), (12), (12), (12), (1)
Applications (56), (24), (24), (17), (16), (15), (13), (10), (8), (4), (1), (1)
Conjugates (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (5), (3), (1), (1), (1), (1), (1), (1)
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