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PDE11A antibody (phosphodiesterase 11A) (AA 34-63)

Details for Product anti-PDE11A Antibody No. ABIN657923, Supplier: Login to see
Antigen
  • si:ch211-222f23.5
  • pde11a
  • pde11a1
  • wu:ft39g12
  • PDE11A
  • ppnad2
  • Pde11a
  • PPNAD2
  • 6330414F14Rik
  • A630086N24Rik
  • Gm350
  • PDE11A1
Epitope
AA 34-63, N-Term
25
21
15
10
6
6
4
2
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
66
23
20
5
2
2
2
2
2
1
1
1
1
1
1
Host
Rabbit
50
20
Clonality (Clone)
Polyclonal ()
Conjugate
This PDE11A antibody is un-conjugated
8
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
59
41
27
18
12
6
6
6
2
1
Supplier
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Immunogen This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 AA from the N-terminal region of human PDE11A.
Clone RB33858
Isotype Ig
Specificity This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human PDE11A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PDE11A (PDE11A Antibody Abstract)
Background The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A,50940,
Molecular Weight 104752 DA
Gene ID 50940
NCBI Accession NP_001070826, NP_001070664, NP_001070665
UniProt Q9HCR9
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment PDE11A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PDE11A antibody (phosphodiesterase 11A) (AA 34-63) (ABIN657923) PDE11A Antibody (N-term) (ABIN657923) western blot analysis in mouse stomach tissue l...
Background publications DeWan, Triche, Xu et al.: "PDE11A associations with asthma: results of a genome-wide association scan." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 871-873.e9, 2010 (PubMed).