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Details for Product No. ABIN657923

phosphodiesterase 11A (PDE11A) (N-Term), (AA 34-63) antibody

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Antigen
Synonyms PPNAD2, Gm350, PDE11A1, 6330414F14Rik, A630086N24Rik, si:ch211-222f23.5, pde11a, pde11a1, wu:ft39g12, PDE11A, ppnad2, Pde11a
Epitope
»Alternatives N-Term, AA 34-63
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN657923
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 AA from the N-terminal region of human PDE11A.
Clone RB33858
Isotype Ig
Specificity This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human PDE11A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PDE11A
Background The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A,50940,
Molecular Weight 104752 DA
Gene ID 50940
UniProt NP_001070664.1, Q9HCR9, NP_001070665.1, NP_001070826.1
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment PDE11A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications DeWan, Triche, Xu et al.: "PDE11A associations with asthma: results of a genome-wide association scan." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 871-873.e9, 2010 (PubMed).

Alternatives for antigen "phosphodiesterase 11A (PDE11A)", type "Antibodies"
Hosts (27), (9)
Reactivities (28), (10), (10), (5)
Applications (27), (10), (9), (9), (4), (3)
Conjugates (1), (1)
Epitopes (7), (6), (5), (2), (1), (1), (1)
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