phosphodiesterase 11A (PDE11A) (N-Term), (AA 34-63) antibody

Details for Product No. ABIN657923
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Antigen
Synonyms si:ch211-222f23.5, pde11a, pde11a1, wu:ft39g12, PDE11A, ppnad2, Pde11a, PPNAD2, 6330414F14Rik, A630086N24Rik, Gm350, PDE11A1
Epitope
N-Term, AA 34-63
(12), (8), (7), (7), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(32), (10), (8), (4)
Host
Rabbit
(31), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(31), (13), (10), (10), (9), (3)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN657923
291.50 $
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Immunogen This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 34-63 AA from the N-terminal region of human PDE11A.
Clone RB33858
Isotype Ig
Specificity This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human PDE11A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name PDE11A
Background The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A,50940,
Molecular Weight 104752 DA
Gene ID 50940
NCBI Accession NP_001070826, NP_001070664, NP_001070665
UniProt Q9HCR9
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment PDE11A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-phosphodiesterase 11A (PDE11A) (N-Term), (AA 34-63) antibody PDE11A Antibody (N-term) (ABIN657923) western blot analysis in mouse stomach tissue lysates (35 µg/lane). This demonstrates the PDE11A antibody detected the PDE11A protein (arrow).
Background publications DeWan, Triche, Xu et al.: "PDE11A associations with asthma: results of a genome-wide association scan." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 871-873.e9, 2010 (PubMed).

Validation Images
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