phosphodiesterase 11A (PDE11A) (N-Term) antibody

Antigen: phosphodiesterase 11A (PDE11A)

Synonyms: PPNAD2, FLJ23693, MGC133355, MGC133356, Gm350, PDE11A1, 6330414F14Rik, A630086N24Rik, PDE11A, si:ch211-222f23.5, pde11a, wu:ft39g12, Pde11a

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657923

Additional Information

Alternative name: PDE11A

Gene ID: 50940

UniProt: NP_001070664.1, Q9HCR9, NP_001070665.1, NP_001070826.1

Immunogen: This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human PDE11A.

Isotype: Ig

Description: Other names: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A,50940,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PDE11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-63 amino acids from the N-terminal region of human PDE11A.

Molecular Weight: 104752 DA

Comments:

Background: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: PDE11A Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Protein Modifications, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

PDE11A Antibody (N-term) (ABIN657923) western blot analysis in mouse stomach tissue lysates (35ug/lane). This demonstrates the PDE11A antibody detected the PDE11A protein (arrow).

Publications

Product: DeWan, Triche, Xu et al.: "PDE11A associations with asthma: results of a genome-wide association scan." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 4, pp. 871-873.e9, 2010 (PubMed).