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Retinoblastoma Binding Protein 8 antibody (RBBP8) (AA 763-792)

Details for Product anti-RBBP8 Antibody No. ABIN657950, Supplier: Log in to see
Antigen
  • 9930104E21Rik
  • COM1
  • CTIP
  • CtIP
  • DKFZp469K0714
  • JWDS
  • RBBP-8
  • RBBP8
  • RGD1308872
  • RIM
  • SAE2
  • SCKL2
Alternatives
anti-Human Retinoblastoma Binding Protein 8 antibody for Immunocytochemistry
Epitope
AA 763-792, C-Term
28
15
10
6
6
4
4
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
117
44
19
4
2
1
Host
Rabbit
91
17
9
Clonality (Clone)
Polyclonal ()
Conjugate
This Retinoblastoma Binding Protein 8 antibody is un-conjugated
4
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
89
56
32
25
23
19
15
13
2
1
1
1
Supplier
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Immunogen This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 763-792 AA from the C-terminal region of human RBBP8.
Clone RB34059
Isotype Ig
Specificity This RBBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 762-792 amino acids from the C-terminal region of human RBBP8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RBBP8 (RBBP8 Antibody Abstract)
Background The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Synonyms: DNA endonuclease RBBP8,5932,CTIP
Molecular Weight 101942 DA
Gene ID 5932
NCBI Accession NP_976037, NP_976036, NP_002885
UniProt Q99708
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Transcription Factors, Chromatin, Signaling, Metabolism, Cell Structure
Pathways Cell Division Cycle, DNA Damage Repair
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RBBP8 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Retinoblastoma Binding Protein 8 antibody (RBBP8) (AA 763-792) (ABIN657950) RBBP8 Antibody (C-term) (ABIN657950) western blot analysis in CEM cell line lysates (...
Background publications Kaidi, Weinert, Choudhary, Jackson: "Human SIRT6 promotes DNA end resection through CtIP deacetylation." in: Science (New York, N.Y.), Vol. 329, Issue 5997, pp. 1348-53, 2010

Thye, Vannberg, Wong, Owusu-Dabo, Osei, Gyapong, Sirugo, Sisay-Joof, Enimil, Chinbuah, Floyd, Warndorff, Sichali, Malema, Crampin, Ngwira, Teo, Small, Rockett, Kwiatkowski, Fine, Hill, Newport et al.: "Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2." in: Nature genetics, Vol. 42, Issue 9, pp. 739-41, 2010