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LMO2 antibody (LIM Domain Only 2 (Rhombotin-Like 1)) (AA 1-30)

Details for Product anti-LMO2 Antibody No. ABIN658023, Supplier: Log in to see
Antigen
  • Rbtn-2
  • Rbtn2
  • Rhom-2
  • Ttg2
  • RBTN2
  • RBTNL1
  • RHOM2
  • TTG2
  • wu:fc83a08
  • zgc:111930
  • LMO-2
  • lmo2-A
  • xlmo2
  • rhombotin-2
Epitope
AA 1-30, N-Term
24
16
8
5
3
2
2
1
Reactivity
Human
90
7
5
3
2
1
1
1
1
1
1
1
1
Host
Rabbit
51
40
3
Clonality (Clone)
Polyclonal ()
Conjugate
This LMO2 antibody is un-conjugated
3
3
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
71
32
30
28
15
6
6
2
1
Supplier
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Immunogen This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human LMO2.
Clone RB33753
Isotype Ig
Specificity This LMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LMO2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name LMO2 (LMO2 Antibody Abstract)
Background LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms: Rhombotin-2,LMO2,RBTN2, RBTNL1, RHOM2, TTG2
Molecular Weight 18358 DA
Gene ID 4005
NCBI Accession NP_001135788, NP_005565, NP_001135787
UniProt P25791
Research Area Cancer, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment LMO2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LMO2 antibody (LIM Domain Only 2 (Rhombotin-Like 1)) (AA 1-30) (ABIN658023) LMO2 Antibody (N-term) (ABIN658023) western blot analysis in NCI-H460 cell line lysat...
Background publications Younes, Beck, Lossos et al.: "Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components." in: The American journal of surgical pathology, Vol. 34, Issue 9, pp. 1266-76, 2010 (PubMed).

Oram, Thoms, Pridans et al.: "A previously unrecognized promoter of LMO2 forms part of a transcriptional regulatory circuit mediating LMO2 expression in a subset of T-acute lymphoblastic leukaemia patients." in: Oncogene, Vol. 29, Issue 43, pp. 5796-808, 2010 (PubMed).

Durnick, Law, Maurer et al.: "Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma." in: American journal of clinical pathology, Vol. 134, Issue 2, pp. 278-81, 2010 (PubMed).

Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).