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Details for Product No. ABIN658030

Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) (C-Term), (AA 508-537) antibody

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Antigen
Synonyms PPK, KLK3, KLKB1, DKFZp459J2015
Epitope
»Alternatives C-Term, AA 508-537
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN658030
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-537 AA from the C-terminal region of human KLKB1.
Clone RB34055
Isotype Ig
Specificity This KLKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 507-537 amino acids from the C-terminal region of human KLKB1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KLKB1
Background Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Synonyms: Plasma kallikrein,KLKB1,KLK3
Molecular Weight 71370 DA
Gene ID 3818
UniProt P03952, NP_000883.2
Research Area Cell Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.47 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment KLKB1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Rajaraman, Brenner, Neta et al.: "Risk of meningioma and common variation in genes related to innate immunity." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 5, pp. 1356-61, 2010 (PubMed).

Alternatives for antigen "Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1)", type "Antibodies"
Hosts (27), (4), (3), (1), (1)
Reactivities (34), (14), (13), (12), (12), (1), (1)
Applications (20), (19), (10), (6), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (4), (2), (1), (1), (1), (1)
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