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Cofilin 2 antibody (Cofilin 2 (Muscle)) (AA 25-54)

Details for Product anti-CFL2 Antibody No. ABIN658038, Supplier: Login to see
Antigen
  • CFL2
  • wu:fb17d06
  • wu:fb18d11
  • wu:fd59f08
  • wu:fj34b08
  • xac1
  • xac2
  • zgc:77288
  • cf12
  • NEM7
Alternatives
anti-Human Cofilin 2 antibody for Western Blotting
Epitope
AA 25-54, N-Term
23
11
8
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
66
21
16
5
5
2
1
1
1
1
1
1
Host
Rabbit
40
22
6
Clonality (Clone)
Polyclonal ()
Conjugate
This Cofilin 2 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
38
16
16
9
6
2
1
1
1
1
1
1
Supplier
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Immunogen This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 AA from the N-terminal region of human CFL2.
Clone RB34119
Isotype Ig
Specificity This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-54 amino acids from the N-terminal region of human CFL2.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CFL2 (CFL2 Antibody Abstract)
Background This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Synonyms: Cofilin-2,CFL2,
Molecular Weight 18737 DA
Gene ID 1073
NCBI Accession NP_068733, NP_619579
UniProt Q9Y281
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Neurology, Cell Structure
Pathways Caspase Cascade in Apoptosis
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.48 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CFL2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cofilin 2 antibody (Cofilin 2 (Muscle)) (AA 25-54) (ABIN658038) Western blot analysis of CFL2 (arrow) using rabbit polyclonal CFL2 Antibody (N-term) ...
Western Blotting (WB) image for anti-Cofilin 2 antibody (Cofilin 2 (Muscle)) (AA 25-54) (ABIN658038) CFL2 Antibody (N-term) western blot analysis in human normal Uterus tissue lysates (...
Immunohistochemistry (IHC) image for anti-Cofilin 2 antibody (Cofilin 2 (Muscle)) (AA 25-54) (ABIN658038) CFL2 Antibody (N-term) (AP14117a)immunohistochemistry analysis in formalin fixed and ...
Background publications Vogel, Wottawa, Farhat et al.: "Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33756-63, 2010 (PubMed).

Agrawal, Greenleaf, Tomczak et al.: "Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2." in: American journal of human genetics, Vol. 80, Issue 1, pp. 162-7, 2006 (PubMed).