Cofilin 2 (Muscle) (CFL2) (N-Term), (AA 25-54) antibody

Details for Product No. ABIN658038
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Antigen
Synonyms CFL2, wu:fb17d06, wu:fb18d11, wu:fd59f08, wu:fj34b08, xac1, xac2, zgc:77288, cf12, NEM7
Epitope
N-Term, AA 25-54
(9), (8), (7), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(42), (10), (7), (3), (3), (1), (1)
Host
Rabbit
(26), (10), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(44), (25), (18), (11), (9), (7), (2), (1), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN658038
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Immunogen This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 AA from the N-terminal region of human CFL2.
Clone RB34119
Isotype Ig
Specificity This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-54 amino acids from the N-terminal region of human CFL2.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CFL2
Background This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Synonyms: Cofilin-2,CFL2,
Molecular Weight 18737 DA
Gene ID 1073
NCBI Accession NP_068733, NP_619579
UniProt Q9Y281
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.48 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CFL2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Cofilin 2 (Muscle) (CFL2) (N-Term), (AA 25-54) antibody Western blot analysis of CFL2 (arrow) using rabbit polyclonal CFL2 Antibody (N-term) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CFL2 gene.
anti-Cofilin 2 (Muscle) (CFL2) (N-Term), (AA 25-54) antibody (2) CFL2 Antibody (N-term) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the CFL2 antibody detected the CFL2 protein (arrow).
anti-Cofilin 2 (Muscle) (CFL2) (N-Term), (AA 25-54) antibody (3) CFL2 Antibody (N-term) (AP14117a)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CFL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Agrawal, Greenleaf, Tomczak et al.: "Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2." in: American journal of human genetics, Vol. 80, Issue 1, pp. 162-7, 2006 (PubMed).

Vogel, Wottawa, Farhat et al.: "Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 33756-63, 2010 (PubMed).

Validation Images
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