Wingless-Type MMTV Integration Site Family, Member 3 (WNT3) (AA 155-184), (Center) antibody

Details for Product No. ABIN658051
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Antigen
Epitope
AA 155-184, Center
(12), (7), (2), (1), (1)
Reactivity
Human
(26), (7), (5), (4)
Host
Rabbit
(14), (7), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(26), (14), (7), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN658051
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Immunogen This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 AA from the Central region of human WNT3.
Clone RB34217
Isotype Ig
Specificity This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-184 amino acids from the Central region of human WNT3.
Predicted Reactivity Chicken,Mouse (Murine),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WNT3
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
Synonyms: Proto-oncogene Wnt-3,WNT3,INT4
Molecular Weight 39645 DA
Gene ID 7473
NCBI Accession NP_110380
UniProt P56703
Research Area Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment WNT3 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Wingless-Type MMTV Integration Site Family, Member 3 (WNT3) (AA 155-184), (Center) antibody WNT3 Antibody (Center) (ABIN658051) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the WNT3 antibody detected the WNT3 protein (arrow).
Background publications Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression...." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Nikopensius, Jagomägi, Krjutskov et al.: "Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 9, pp. 748-56, 2010 (PubMed).

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