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Details for Product No. ABIN658051

Wingless-Type MMTV Integration Site Family, Member 3 (WNT3) (AA 155-184), (Center) antibody

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Synonyms INT4, Int-4, Wnt-3, Xwnt-3, Xwnt3, wnt-3, wnt3-A, wnt3l, Ci-Wnt3, WNT3, int4, wnt3
»Alternatives AA 155-184, Center
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN658051
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 AA from the Central region of human WNT3.
Clone RB34217
Isotype Ig
Specificity This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-184 amino acids from the Central region of human WNT3.
Predicted Reactivity Chicken,Mouse (Murine),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name WNT3
Background The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
Synonyms: Proto-oncogene Wnt-3,WNT3,INT4
Molecular Weight 39645 DA
Gene ID 7473
UniProt P56703, NP_110380.1
Research Area Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment WNT3 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Nikopensius, Jagomägi, Krjutskov et al.: "Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 9, pp. 748-56, 2010 (PubMed).

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