Jumonji Domain Containing 6 (JMJD6) (C-Term) antibody

Antigen: Jumonji Domain Containing 6 (JMJD6)

Synonyms: psr, ptdsr, zfpsr, zgc:66264, PSR, PTDSR, PTDSR1, KIAA0585, BEST:LD22859, L0022859, PS, dPSR, DmelCG5383, CG5383, Ptdsr, PtdSerR, mKIAA0585, D11Ertd195e, 5730436I23Rik, GB15204, JMJD6, MGC128950, jmjd6, DKFZp468K1319

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658081

Additional Information

Alternative name: JMJD6

Gene ID: 23210

UniProt: NP_055982.2, Q6NYC1, NP_001074930.1

Immunogen: This JMJD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human JMJD6.

Isotype: Ig

Description: Other names: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6,JMJD6,KIAA0585, PTDSR

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This JMJD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-311 amino acids from the C-terminal region of human JMJD6.

Molecular Weight: 46462 DA

Comments:

Background: This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Synonyms: psr, ptdsr, zfpsr, zgc:66264, PSR, PTDSR, PTDSR1, KIAA0585, BEST:LD22859, L0022859, PS, dPSR, DmelCG5383, CG5383, Ptdsr, PtdSerR, mKIAA0585, D11Ertd195e, 5730436I23Rik, GB15204, JMJD6, MGC128950, jmjd6, DKFZp468K1319

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: JMJD6 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Cell Cycle, Transcription Factors, Chromatin, Signaling, Cell Structure

Restrictions: For Research Use only

Images

JMJD6 Antibody (C-term) (ABIN658081) western blot analysis in K562 cell line lysates (35ug/lane). This demonstrates the JMJD6 antibody detected the JMJD6 protein (arrow).

Publications

Product: Zakharova, Dadsetan, Fomina: "Endogenous Jmjd6 gene product is expressed at the cell surface and regulates phagocytosis in immature monocyte-like activated THP-1 cells." in: Journal of cellular physiology, Vol. 221, Issue 1, pp. 84-91, 2009 (PubMed).

Webby, Wolf, Gromak et al.: "Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing." in: Science (New York, N.Y.), Vol. 325, Issue 5936, pp. 90-3, 2009 (PubMed).

Hong, Zang, White et al.: "Interaction of JMJD6 with single-stranded RNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 33, pp. 14568-72, 2010 (PubMed).

Mantri, Krojer, Bagg et al.: "Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6." in: Journal of molecular biology, Vol. 401, Issue 2, pp. 211-22, 2010 (PubMed).