UBP46 (C-Term) antibody

Antigen: UBP46

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658082

Additional Information

Gene ID: 64854

UniProt: NP_001127695.1, P62068, NP_073743.2

Immunogen: This UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the C-terminal region of human UBP46.

Isotype: Ig

Description: Other names: Ubiquitin carboxyl-terminal hydrolase 46,USP46,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This UBP46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the C-terminal region of human UBP46.

Molecular Weight: 42442 DA

Comments:

Background: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: UBP46 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Images

UBP46 Antibody (C-term) (ABIN658082) western blot analysis in MDA-MB231 cell line lysates (35ug/lane). This demonstrates the UBP46 antibody detected the UBP46 protein (arrow).

Publications

Product: Puente, Sánchez, Overall et al.: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, 2003 (PubMed).

Kushima, Aleksic, Ito et al.: "Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population." in: Journal of human genetics, Vol. 55, Issue 3, pp. 133-6, 2010 (PubMed).