Huntingtin Interacting Protein 1 (HIP1) (Center) antibody

Antigen: Huntingtin Interacting Protein 1 (HIP1)

Synonyms: ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658105

Additional Information

Alternative name: HIP1

Gene ID: 3092

UniProt: NP_005329.3, O00291

Immunogen: This HIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-453 amino acids from the Central region of human HIP1.

Isotype: Ig

Description: Other names: Huntingtin-interacting protein 1,HIP1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This HIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-453 amino acids from the Central region of human HIP1.

Molecular Weight: 116221 DA

Comments:

Background: The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined.

Synonyms: ILWEQ, MGC126506, CG10971, DmelCG10971, KIAA4113, MGC27616, mKIAA4113, 2610109B09Rik, A930014B11Rik, E130315I21Rik, HYPB, SET2, HIF-1, KMT3A, HBP231, HSPC069, p231HBP, FLJ16420, FLJ22472, FLJ23184, FLJ45883, FLJ46217, KIAA1732, hip1, MGC78813, HIP1

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: HIP1 Antibody (Center) can be refrigerated at 2-8° C for up to 6 months. For long term storage, place the at -20° C.

Research Area: Translation Factors, Protein Modifications, Signaling, Neurology, Cell Structure, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Cycle, Transcription Factors, Chromatin

Restrictions: For Research Use only

Images

HIP1 Antibody (Center) (ABIN658105) western blot analysis in A549 cell line lysates (35ug/lane). This demonstrates the HIP1 antibody detected the HIP1 protein (arrow).

Publications

Product: Niu, Ybe: "Crystal structure at 2.8 A of Huntingtin-interacting protein 1 (HIP1) coiled-coil domain reveals a charged surface suitable for HIP1 protein interactor (HIPPI)." in: Journal of molecular biology, Vol. 375, Issue 5, pp. 1197-205, 2008 (PubMed).

Wilbur, Hwang, Brodsky et al.: "Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain." in: Acta crystallographica. Section D, Biological crystallography, Vol. 66, Issue Pt 3, pp. 314-8, 2010 (PubMed).