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Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 239-268), (N-Term) antibody

Details for Product No. ABIN658114, Supplier: Log in to see
Antigen
  • 1300004C08Rik
  • Ube1l
  • UBE1
  • UBE1L
  • UBE1L2
  • xubc3
  • D8
  • UBA1B
  • UBE2
Epitope
AA 239-268, N-Term
19
15
10
8
6
2
2
1
1
1
1
1
1
Reactivity
Human
78
16
15
Host
Rabbit
66
16
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
61
41
34
12
11
5
3
2
1
1
Supplier
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Immunogen This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 AA from the N-terminal region of human UBA7.
Clone RB33937
Isotype Ig
Specificity This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-268 amino acids from the N-terminal region of human UBA7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UBA7 (UBA7 Antibody Abstract)
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].
Synonyms: Ubiquitin-like modifier-activating enzyme 7,UBA7,UBE1L, UBE2
Molecular Weight 111694 DA
Gene ID 7318
NCBI Accession NP_003326
UniProt P41226
Research Area Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment UBA7 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (AA 239-268), (N-Term) antibody (ABIN658114) UBA7 Antibody (N-term) (ABIN658114) western blot analysis in CEM cell line lysates (3...
Background publications Fransen, Visschedijk, van Sommeren et al.: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Morgan, Han, Lam et al.: "Association analysis of 3p21 with Crohn's disease in a New Zealand population." in: Human immunology, Vol. 71, Issue 6, pp. 602-9, 2010 (PubMed).

Takeuchi, Iwahara, Saeki et al.: "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme." in: Journal of biochemistry, Vol. 138, Issue 6, pp. 711-9, 2006 (PubMed).