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Details for Product No. ABIN658114

Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term), (AA 239-268) antibody

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Antigen
Synonyms D8, UBA1B, UBE1L, UBE2, 1300004C08Rik, Ube1l, UBE1, UBE1L2, xubc3
Epitope
»Alternatives N-Term, AA 239-268
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN658114
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 AA from the N-terminal region of human UBA7.
Clone RB33937
Isotype Ig
Specificity This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-268 amino acids from the N-terminal region of human UBA7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UBA7
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].
Synonyms: Ubiquitin-like modifier-activating enzyme 7,UBA7,UBE1L, UBE2
Molecular Weight 111694 DA
Gene ID 7318
UniProt NP_003326.2, P41226
Research Area Signaling, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment UBA7 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Takeuchi, Iwahara, Saeki et al.: "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme." in: Journal of biochemistry, Vol. 138, Issue 6, pp. 711-9, 2006 (PubMed).

Morgan, Han, Lam et al.: "Association analysis of 3p21 with Crohn's disease in a New Zealand population." in: Human immunology, Vol. 71, Issue 6, pp. 602-9, 2010 (PubMed).

Fransen, Visschedijk, van Sommeren et al.: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

Alternatives for antigen "Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7)", type "Antibodies"
Hosts (34), (14)
Reactivities (48), (12), (12), (12), (12)
Applications (35), (19), (12), (11), (10), (5), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (4), (2), (1), (1), (1), (1), (1)
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