Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term), (AA 239-268) antibody

Details for Product No. ABIN658114
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Antigen
Epitope
N-Term, AA 239-268
(8), (7), (6), (4), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(57), (13), (13), (12), (12)
Host
Rabbit
(44), (15)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(47), (31), (20), (12), (10), (6), (3), (2), (2), (2)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN658114
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Immunogen This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 AA from the N-terminal region of human UBA7.
Clone RB33937
Isotype Ig
Specificity This UBA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-268 amino acids from the N-terminal region of human UBA7.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UBA7
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq].
Synonyms: Ubiquitin-like modifier-activating enzyme 7,UBA7,UBE1L, UBE2
Molecular Weight 111694 DA
Gene ID 7318
NCBI Accession NP_003326
UniProt P41226
Research Area Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment UBA7 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7) (N-Term), (AA 239-268) antibody UBA7 Antibody (N-term) (ABIN658114) western blot analysis in CEM cell line lysates (35 µg/lane). This demonstrates the UBA7 antibody detected the UBA7 protein (arrow).
Background publications Takeuchi, Iwahara, Saeki et al.: "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme." in: Journal of biochemistry, Vol. 138, Issue 6, pp. 711-9, 2006 (PubMed).

Morgan, Han, Lam et al.: "Association analysis of 3p21 with Crohn's disease in a New Zealand population." in: Human immunology, Vol. 71, Issue 6, pp. 602-9, 2010 (PubMed).

Fransen, Visschedijk, van Sommeren et al.: "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3482-8, 2010 (PubMed).

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