Matrin 3 (MATR3) (N-Term) antibody

Antigen: Matrin 3 (MATR3)

Synonyms: MGC9105, KIAA0723, DKFZp686K0542, DKFZp686K23100, AI841759, AW555618, mKIAA0723, 1110061A14Rik, 2810017I02Rik, D030046F20Rik, P130/MAT3, MGC80752, matr3, MGC79524, MATR3, MGC140178, DKFZp459A057, DKFZp459A162, DKFZp459F0515, DKFZp469A1933, LOC100232255

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658127

Additional Information

Alternative name: MATR3

Gene ID: 9782

UniProt: NP_954659.1, NP_001181883.1, P43243

Immunogen: This MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-186 amino acids from the N-terminal region of human MATR3.

Isotype: Ig

Description: Other names: Matrin-3,MATR3,KIAA0723

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-186 amino acids from the N-terminal region of human MATR3.

Molecular Weight: 94623 DA

Comments:

Background: This locus encodes a nuclear matrix protein. Mutations at this locus have been associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts with an upstream locus have been described. Related pseuodgenses have been defined on chr1 and chrX.

Synonyms: MGC9105, KIAA0723, DKFZp686K0542, DKFZp686K23100, AI841759, AW555618, mKIAA0723, 1110061A14Rik, 2810017I02Rik, D030046F20Rik, P130/MAT3, MGC80752, matr3, MGC79524, MATR3, MGC140178, DKFZp459A057, DKFZp459A162, DKFZp459F0515, DKFZp469A1933, LOC100232255

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: MATR3 Antibody (N-term) can be refrigerated at 2-8° C for up to 6 months. For long term storage, place the at -20° C.

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

MATR3 Antibody (N-term) (ABIN658127) western blot analysis in 293 cell line lysates (35ug/lane). This demonstrates the MATR3 antibody detected the MATR3 protein (arrow).

Publications

Product: Malyavantham, Bhattacharya, Barbeitos et al.: "Identifying functional neighborhoods within the cell nucleus: proximity analysis of early S-phase replicating chromatin domains to sites of transcription, RNA polymerase II, HP1gamma, matrin 3 and SAF-A." in: Journal of cellular biochemistry, Vol. 105, Issue 2, pp. 391-403, 2008 (PubMed).

Graubert, Payton, Shao et al.: "Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis." in: PLoS ONE, Vol. 4, Issue 2, pp. e4583, 2009 (PubMed).

Senderek, Garvey, Krieger et al.: "Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3." in: American journal of human genetics, Vol. 84, Issue 4, pp. 511-8, 2009 (PubMed).

Zeitz, Malyavantham, Seifert et al.: "Matrin 3: chromosomal distribution and protein interactions." in: Journal of cellular biochemistry, Vol. 108, Issue 1, pp. 125-33, 2009 (PubMed).