Microcephalin 1 (MCPH1) (N-Term) antibody

Antigen: Microcephalin 1 (MCPH1)

Synonyms: MCT, BRIT1, FLJ12847, RGD1560642, MGC83773, MCPH1, mct, brit1, MGC148665

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658137

Additional Information

Alternative name: MCPH1

Gene ID: 79648

UniProt: NP_078872.2, Q8NEM0, NP_001166045.1

Immunogen: This MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the N-terminal region of human MCPH1.

Isotype: Ig

Description: Other names: Microcephalin,MCPH1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This MCPH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-133 amino acids from the N-terminal region of human MCPH1.

Molecular Weight: 92877 DA

Comments:

Background: This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: MCPH1 Antibody (N-term) can be refrigerated at 2-8° C for up to 6 months. For long term storage, place the at -20° C.

Research Area: Protein Modifications, Neurology, Cell Structure, Phospho-specific antibodies

Restrictions: For Research Use only

Images

MCPH1 Antibody (N-term) (ABIN658137) western blot analysis in HL-60 cell line lysates (35ug/lane). This demonstrates the MCPH1 antibody detected the MCPH1 protein (arrow).

Publications

Product: Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Wang, Fu, Xie et al.: "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population." in: Journal of human genetics, Vol. 55, Issue 8, pp. 490-4, 2010 (PubMed).

Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).