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Details for Product No. ABIN658140

High Mobility Group Nucleosome Binding Domain 1 (HMGN1) (N-Term), (AA 1-30) antibody

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Antigen
Synonyms HMG14, HMG-14, Hmg14, hmg14, hmgn1, hmgn1b
Epitope
»Alternatives N-Term, AA 1-30
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN658140
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This HMGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human HMGN1.
Clone RB34198
Isotype Ig
Specificity This HMGN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HMGN1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name HMGN1
Background Chromosomal protein HMG14 and its close analog HMG17 (MIM 163910) bind to the inner side of the nucleosomal DNA, potentially altering the interaction between the DNA and the histone octamer. The 2 proteins may be involved in the process that maintains transcribable genes in a unique chromatin conformation. Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function.
Synonyms: Non-histone chromosomal protein HMG-14,HMGN1,HMG14
Molecular Weight 10659 DA
Gene ID 3150
UniProt P05114, NP_004956.5
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HMGN1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Jiang, Wang: "Phosphorylation of human high mobility group N1 protein by protein kinase CK2." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1497-503, 2006 (PubMed).

Zhu, Hansen: "HMGN1 modulates estrogen-mediated transcriptional activation through interactions with specific DNA-binding transcription factors." in: Molecular and cellular biology, Vol. 27, Issue 24, pp. 8859-73, 2007 (PubMed).

Cherukuri, Hock, Ueda et al.: "Cell cycle-dependent binding of HMGN proteins to chromatin." in: Molecular biology of the cell, Vol. 19, Issue 5, pp. 1816-24, 2008 (PubMed).

Rattner, Yusufzai, Kadonaga: "HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility." in: Molecular cell, Vol. 34, Issue 5, pp. 620-6, 2009 (PubMed).

Alternatives for antigen "High Mobility Group Nucleosome Binding Domain 1 (HMGN1)", type "Antibodies"
Hosts (47)
Reactivities (46), (38), (38), (29), (28), (26), (26), (2), (2), (1)
Applications (23), (20), (17), (13), (12), (8), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (16), (5), (3), (2), (2), (2), (1), (1)
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