Uromodulin (UMOD) (AA 352-380), (Center) antibody

Details for Product No. ABIN658177
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Antigen
Epitope
AA 352-380, Center
(11), (7), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(97), (43), (39), (35), (11), (10), (1)
Host
Rabbit
(73), (19), (12), (2), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(53), (35), (29), (26), (19), (16), (9), (9), (9), (7), (4), (3), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN658177
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Immunogen This UMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-380 AA from the Central region of human UMOD.
Clone RB34670
Isotype Ig
Specificity This UMOD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the Central region of human UMOD.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name UMOD
Background This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Synonyms: Uromodulin,UMOD,
Molecular Weight 69761 DA
Gene ID 7369
NCBI Accession NP_001008390, NP_003352
UniProt P07911
Research Area Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment UMOD Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Uromodulin (UMOD) (AA 352-380), (Center) antibody UMOD Antibody (Center) (ABIN658177) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the UMOD antibody detected the UMOD protein (arrow).
Background publications Johnson, Drugan, Miller et al.: "38" in: 299-308, Vol. 1363, Issue Nucleic acids research, pp. 28-39, 1991

Pattaro, De Grandi, Vitart et al.: "A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level." in: BMC medical genetics, Vol. 11, pp. 41, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

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