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AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (AA 227-256), (C-Term) antibody

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Synonyms MGC81452, lobe, pras40, fb34a04, wu:fb34a04, Lobe, PRAS40, 1110012J22Rik, AI227026, Lobel
AA 227-256, C-Term
(30), (15), (12), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(88), (22), (20), (5), (1)
(67), (21)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (3), (3), (3), (2), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(80), (38), (27), (9), (8), (4), (3)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This AKT1S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 AA from the C-terminal region of human AKT1S1.
Clone RB34859
Isotype Ig
Specificity This AKT1S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-256 amino acids from the C-terminal region of human AKT1S1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKT1S1 (AKT1S1 Antibody Abstract)
Background AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM].
Synonyms: Proline-rich AKT1 substrate 1,AKT1S1,PRAS40
Molecular Weight 27383 DA
Gene ID 84335
NCBI Accession NP_001092102, NP_001092103, NP_115751
Research Area Protein Modifications, Cell Structure, Phospho-specific antibodies
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment AKT1S1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (AA 227-256), (C-Term) antibody (ABIN658196) AKT1S1 Antibody (C-term) (ABIN658196) western blot analysis in Hela cell line lysates...
Background publications Wang, Harris, Lawrence: "Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15619-27, 2008 (PubMed).

Wang, Harris, Roth et al.: "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding." in: The Journal of biological chemistry, Vol. 282, Issue 27, pp. 20036-44, 2007 (PubMed).

Sancak, Thoreen, Peterson et al.: "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase." in: Molecular cell, Vol. 25, Issue 6, pp. 903-15, 2007 (PubMed).

Catalog No. ABIN658196
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