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Details for Product No. ABIN658196

AKT1 Substrate 1 (Proline-Rich) (AKT1S1) (C-Term), (AA 227-256) antibody

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Antigen
Synonyms Lobe, Lobel, PRAS40, AI227026, 1110012J22Rik, MGC81452, lobe, pras40, fb34a04, wu:fb34a04
Epitope
»Alternatives C-Term, AA 227-256
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN658196
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This AKT1S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 AA from the C-terminal region of human AKT1S1.
Clone RB34859
Isotype Ig
Specificity This AKT1S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-256 amino acids from the C-terminal region of human AKT1S1.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKT1S1
Background AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM].
Synonyms: Proline-rich AKT1 substrate 1,AKT1S1,PRAS40
Molecular Weight 27383 DA
Gene ID 84335
UniProt NP_115751.2, NP_001092103.1, NP_001092102.1
Research Area Protein Modifications, Cell Structure, Phospho-specific antibodies
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment AKT1S1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Sancak, Thoreen, Peterson et al.: "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase." in: Molecular cell, Vol. 25, Issue 6, pp. 903-15, 2007 (PubMed).

Wang, Harris, Roth et al.: "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding." in: The Journal of biological chemistry, Vol. 282, Issue 27, pp. 20036-44, 2007 (PubMed).

Wang, Harris, Lawrence: "Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15619-27, 2008 (PubMed).

Alternatives for antigen "AKT1 Substrate 1 (Proline-Rich) (AKT1S1)", type "Antibodies"
Hosts (47), (8)
Reactivities (54), (33), (32), (25), (25), (12)
Applications (36), (20), (16), (10), (6), (3), (1)
Conjugates (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (19), (5), (1), (1), (1), (1)
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