TEA Domain Family Member 2 (TEAD2) (AA 267-295), (Center) antibody

Details for Product No. ABIN658203
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Antigen
Synonyms ETF, TEAD-2, TEF-4, TEF4, Etdf, TEAD2
Epitope
AA 267-295, Center
(8), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(29), (10), (3), (3), (1), (1), (1)
Host
Rabbit
(17), (9), (3)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
(15), (14), (9), (7), (5), (3), (1), (1)
Pubmed 2 references available
Catalog no. ABIN658203
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 AA from the Central region of human TEAD2.
Clone RB34876
Isotype Ig
Specificity This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human TEAD2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TEAD2
Background Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Synonyms: Transcriptional enhancer factor TEF-4,TEAD2,TEF4
Molecular Weight 49243 DA
Gene ID 8463
UniProt NP_003589.1, Q15562
Research Area Transcription Factors, Translation Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TEAD2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-TEA Domain Family Member 2 (TEAD2) (AA 267-295), (Center) antibody TEAD2 Antibody (Center) (ABIN658203) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the TEAD2 antibody detected the TEAD2 protein (arrow).
Background publications Zhao, Ye, Yu et al.: "TEAD mediates YAP-dependent gene induction and growth control." in: Genes & development, Vol. 22, Issue 14, pp. 1962-71, 2008 (PubMed).

Zhang, Liu, Zha et al.: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13355-62, 2009 (PubMed).

Hosts (17), (9), (3)
Reactivities (29), (10), (3), (3), (1), (1), (1)
Applications (15), (14), (9), (7), (5), (3), (1), (1)
Epitopes (8), (3), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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